Wtip CLIA Kit for Mouse(Mus musculus) | EIAab.comWtip CLIA Kit for Mouse(Mus musculus)

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Wtip (Gene name),

Wilms tumor protein 1-interacting protein (Protein name ), WTIP_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Wtip;

Protein name:

Wilms tumor protein 1-interacting protein(WT1-interacting protein);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with CD2AP and WT1.

Function:

May monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes. In case of podocyte injury, it shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype.

Subcellular Location:

Cell junction adherens junction Nucleus Translocates from cell-cell junctions to the nucleus in puromycin aminonucleoside-treated podocytes.

Protein Attributes:

Sequence length:

398

Sequence:

50:

100:

150:

200:

250:

300:

350:

398:

CEDCGLQLSG | EEGRRCYPLE | GHLLCRRCHL | RRLGQGPLPS | PAVHVTEL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.422738

KEGG:

mmu:101543

SMR:

Q7TQJ8

STRING:

10090.ENSMUSP00000047623

String:

Q7TQJ8

Pfam:

PF00412

Uniprot:

Q7TQJ8

FOR

ELISA Kit for Mouse WT1-interacting protein

Cat.:

E2052h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Mouse WT1-interacting protein

Cat.:

E2052m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse WT1-interacting protein

Cat.:

U2052h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse WT1-interacting protein

Cat.:

U2052m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Mouse WT1-interacting protein

Cat.:

P2052Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse WT1-interacting protein

Cat.:

P2052Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse WT1-interacting protein

Protein for Mouse WT1-interacting protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Limb.
3.

"A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus."
Srichai M.B. , Konieczkowski M. , Padiyar A. , Konieczkowski D.J. , Mukherjee A. , Hayden P.S. , Kamat S. , El-Meanawy M.A. , Khan S. , Mundel P. , Lee S.B. , Bruggeman L.A. , Schelling J.R. , Sedor J.R.
J. Biol. Chem.279:14398-14408(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INTERACTION WITH WT1 AND CD2AP
4.

"WT1-interacting protein and ZO-1 translocate into podocyte nuclei after puromycin aminonucleoside treatment."
Rico M. , Mukherjee A. , Konieczkowski M. , Bruggeman L.A. , Miller R.T. , Khan S. , Schelling J.R. , Sedor J.R.
Am. J. Physiol.289:F431-F441(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
5.

"The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling."
Ayyanathan K. , Peng H. , Hou Z. , Fredericks W.J. , Goyal R.K. , Langer E.M. , Longmore G.D. , Rauscher F.J. III
Cancer Res.67:9097-9106(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus."
Langer E.M. , Feng Y. , Zhaoyuan H. , Rauscher F.J. III , Kroll K.L. , Longmore G.D.
Dev. Cell14:424-436(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNAI1; SNAI2/SLUG AND SCRT1
7.

"The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling."
van Wijk N.V. , Witte F. , Feike A.C. , Schambony A. , Birchmeier W. , Mundlos S. , Stricker S.
Biochem. Biophys. Res. Commun.390:211-216(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ROR2;HOMODIMERIZATION;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE
8.

"Podocyte injury induces nuclear translocation of WTIP via microtubule-dependent transport."
Kim J.H. , Konieczkowski M. , Mukherjee A. , Schechtman S. , Khan S. , Schelling J.R. , Ross M.D. , Bruggeman L.A. , Sedor J.R.
J. Biol. Chem.285:9995-10004(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH MAPK8IP3 AND DYNEIN INTERMEDIATE CHAIN;TISSUE SPECIFICITY
9.

"WT1-interacting protein (Wtip) regulates podocyte phenotype by cell-cell and cell-matrix contact reorganization."
Kim J.H. , Mukherjee A. , Madhavan S.M. , Konieczkowski M. , Sedor J.R.
Am. J. Physiol.302:F103-F115(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION

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